Transposable elements (TEs) are self-replicating DNA elements that constitute major fractions FOIE GRAS of eukaryote genomes.Their ability to transpose can modify the genome structure with potentially deleterious effects.To repress TE activity, host cells have developed numerous strategies, including epigenetic pathways, such as DNA methylation or

Castrate-resistant prostate cancer (CRPC) is the lethal form of prostate cancer.Epithelial mesenchymal plasticity (EMP) has been associated with disease progression to CRPC, and prostate cancer therapies targeting the androgen signalling axis, including androgen deprivation therapy (ADT), promote EMP.We explored effects of castration on EMP in the

Abstract CPD-associated peritonitis is a leading cause of morbidity and mortality for ESRD patients maintained on CPD therapy.The percentage of ESRD patients maintained on CPD therapy is declining.The reasons are unclear, but may be due to concerns about CPD-associated peritonitis.The incidence of CPD-associated peritonitis has decreased largely at

BackgroundPractice variation in healthcare is a complex issue.We focused on practice variation in induction of labor between maternity care networks in the Netherlands.These collaborations of hospitals and midwifery practices are jointly responsible for providing high-quality maternity care.We explored Platform Bed the association between induction

In this work a shared pressure-controlled ventilation device for two patients is considered.By the use of different valves Pot Holder incorporated to the circuit, the device enables the restriction of possible cross contamination and the individualization of tidal volumes, driving pressures, and positive end expiratory pressure PEEP.Possible intera